Clinical QuickieLiver/GI

Albumin

Low albumin does not automatically mean 'needs more protein.'

Albumin Is a Context Marker

Its concentration reflects inflammation, distribution/capillary permeability, renal or GI losses, dilution and hepatic synthetic capacity — not nutrition alone.

A low albumin is a signal to investigate, not a diagnosis.

Inflammation Lowers Albumin

Albumin is a negative acute-phase reactant.

Acute illness can lower it even when calorie and protein intake are adequate.

Find the Mechanism

Heavy proteinuria points toward renal loss; ascites/coagulopathy toward significant liver disease; severe diarrhea/weight loss can suggest GI protein loss.

Fluid status also changes the measured concentration.

Don't Treat the Lab Number

Albumin infusion has selected clinical indications. A low serum albumin by itself is not an indication to replace albumin or diagnose malnutrition.

Treat the underlying mechanism, not the number.

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